N-bromobutanimide → 5-Bromo-6-(3-fluorophenyl)pyrazin-2-amine

HRID 1710677ノート

反応式

HRID 1710677 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([NH2:14])[CH:11]=[N:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[Br:15]N1C(=O)CCC1=O>CS(C)=O.O>[Br:15][C:9]1[N:10]=[CH:11][C:12]([NH2:14])=[N:13][C:8]=1[C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=1

参加物

5

反応物 2

HCID 67184N-bromobutanimideHCID 457883426-(3-Fluorophenyl)pyrazin-2-amine

生成物 1

HCID 594576145-Bromo-6-(3-fluorophenyl)pyrazin-2-amine収率 85%

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒2 回

反応条件

温度
0 °C

実験手順

To a 0° C. cooled stirred solution of 6-(3-fluorophenyl)pyrazin-2-ylamine (0.5 g, 2.64 mmol) in a mixture of DMSO (10 mL) and water (0.25 mL), was added N-bromosuccinimide (0.518 g, 2.90 mmol) in portions. After stirring for 5 h, the mixture was poured into water, the precipitate collected by filtration, washed with water and dried to give the title compound as a yellow solid (0.60 g, 85%).

後処理

  1. filtrationthe precipitate collected by filtration
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-95c2028c50c24acd974485b65098c019
出典データセット
uspto-grants-2010_09
特許番号
US07790728B2

反応ノート

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