Hydrochloric Acid → 4-Morpholineacetic acid

HRID 1711129

反応式

HRID 1711129 の反応式
C[O:2][C:3]([CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH2:8][CH2:7]1)=[O:4].Cl>[OH-].[Na+].C1COCC1>[N:6]1([CH2:5][C:3]([OH:4])=[O:2])[CH2:11][CH2:10][O:9][CH2:8][CH2:7]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 1268178Methyl Morpholinoacetate

生成物 1

HCID 4389684-Morpholineacetic acid収率 90.3%

試薬・触媒・溶媒 1

HCID 20445995Sodium hydroxide tetrahydrofuran溶媒

実験手順

A solution of methyl N-morpholinoacetate (0.85 g, 5.3 mmol) in 1:1 5N NaOH/THF (10 ml) was stirred at 50° C. for 1 h then neutralized to pH 3 with 6N HCl and concentrated. The yellowish solid was diluted with 1:1 MeOH/CH2Cl2 (25 ml), filtered to remove inorganic salts, and concentrated. The dilution, filtration and concentration were repeated to give morpholin-4-yl-acetic acid (695 mg, 90%) as a yellow solid.

後処理

  1. concentrationconcentrated
  2. additionThe yellowish solid was diluted with 1:1 MeOH/CH2Cl2 (25 ml)
  3. filtrationfiltered
  4. customto remove inorganic salts
  5. concentrationconcentrated
  6. filtrationThe dilution, filtration and concentration

出典と根拠

ORDレコード
ord-c839efddee6145ae97f0e0a9e044b0e9
出典データセット
uspto-grants-2010_09
特許番号
US07790747B2

関連ノート

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