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Hydrochloric Acid → 4-Morpholineacetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Methyl Morpholinoacetate | HCID 1268178 | — |
| 溶媒 | Sodium hydroxide tetrahydrofuran | HCID 20445995 | — |
| 生成物 | 4-Morpholineacetic acid | HCID 438968 | 90.3% |
反応手順
A solution of methyl N-morpholinoacetate (0.85 g, 5.3 mmol) in 1:1 5N NaOH/THF (10 ml) was stirred at 50° C. for 1 h then neutralized to pH 3 with 6N HCl and concentrated. The yellowish solid was diluted with 1:1 MeOH/CH2Cl2 (25 ml), filtered to remove inorganic salts, and concentrated. The dilution, filtration and concentration were repeated to give morpholin-4-yl-acetic acid (695 mg, 90%) as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07790747B2 |
| 出典データセット | uspto-grants-2010_09 |
| ORD ID | ord-c839efddee6145ae97f0e0a9e044b0e9 |
| 出典メモ | uspto-grants-2010_09 |