Trifluoroacetic acid → (R)-1-phenyl-N2-(tetrahydro-pyran-4-yl)-ethane-1,2-diamine TFA salt

HRID 1711189ノート

反応式

HRID 1711189 の反応式
C(OC(=O)[NH:7][C@H:8]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH2:9][NH:10][CH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)(C)(C)C.[C:24]([OH:30])([C:26]([F:29])([F:28])[F:27])=[O:25]>C(Cl)Cl>[OH:30][C:24]([C:26]([F:29])([F:28])[F:27])=[O:25].[C:17]1([C@@H:8]([NH2:7])[CH2:9][NH:10][CH:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 68777024[(R)-1-phenyl-2-(tetrahydro-pyran-4-ylamino)-ethyl]-carbamic acid tert-butyl ester

生成物 1

HCID 86629533(R)-1-phenyl-N2-(tetrahydro-pyran-4-yl)-ethane-1,2-diamine TFA salt

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of the tert-butyl carbamate (333 mg, 1.04 mmol) and TFA (1.0 ml) in CH2Cl2 (6.0 ml) was stirred at room temperature for 50 minutes. The excess solvent was removed under reduced pressure, giving the crude (R)-1-phenyl-N2-(tetrahydro-pyran-4-yl)-ethane-1,2-diamine TFA salt as a pale yellow oil (849 mg).

後処理

  1. customThe excess solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-df56fd8f191b4e53924d355121229f7f
出典データセット
uspto-grants-2010_09
特許番号
US07790747B2

反応ノート

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