Trifluoroacetic acid → trans-[2-(4-Bromophenyl)cyclopropyl]amine trifluoroacetic acid salt

HRID 1711595ノート

反応式

HRID 1711595 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[CH2:10][C@H:9]2[NH:11]C(=O)OC(C)(C)C)=[CH:4][CH:3]=1.[C:19]([OH:25])([C:21]([F:24])([F:23])[F:22])=[O:20]>C(Cl)Cl>[F:22][C:21]([F:24])([F:23])[C:19]([OH:25])=[O:20].[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C@@H:8]2[CH2:10][C@H:9]2[NH2:11])=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86658779tert-butyl ((1R,2S)-2-(4-bromophenyl)cyclopropyl)carbamate2 回

生成物 1

HCID 67320059trans-[2-(4-Bromophenyl)cyclopropyl]amine trifluoroacetic acid salt

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of racemic trans-1,1-dimethylethyl [2-(4-bromophenyl)cyclopropyl]carbamate (Intermediate 4) (1.25 g) in 71.5 mL of DCM was cooled to 0° C. TFA (17 mL) was added dropwise and the solution was stirred at this temperature for 1 h. Then the mixture was evaporated in vacuo to obtain 1.83 g of title material as a yellow solid which was used without further purification in the next step.

後処理

  1. customThen the mixture was evaporated in vacuo

出典と根拠

ORDレコード
ord-4c9bf80dc77f4078a2fd1bb908c0f942
出典データセット
uspto-grants-2010_09
特許番号
US07790758B2

反応ノート

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