7-Nitro-3,4-dihydroisoquinolin-1(2H)-one → 7-Amino-1,2,3,4-tetrahydroisoquinolin-1-one

HRID 1711702ノート

反応式

HRID 1711702 の反応式
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][CH2:9][NH:10][C:11]2=[O:14])=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][CH2:9][NH:10][C:11]2=[O:14])=[CH:6][CH:5]=1

参加物

4

反応物 1

HCID 131528427-Nitro-3,4-dihydroisoquinolin-1(2H)-one

生成物 1

HCID 131528447-Amino-1,2,3,4-tetrahydroisoquinolin-1-one収率 84.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A suspension of 7-nitro-3,4-dihydro-2H-isoquinolin-1-one (11.6 g, 60 mmol) and 10% Pd/C (1.2 g) in MeOH was stirred overnight at RT under H2 (40 psi). The mixture was filtered through Celite® and washed with MeOH. The filtrate was evaporated under vacuum to afford 8.2 g of 7-amino-3,4-dihydro-2H-isoquinolin-1-one, which was used without further purification.

後処理

  1. filtrationThe mixture was filtered through Celite®
  2. washwashed with MeOH
  3. customThe filtrate was evaporated under vacuum

出典と根拠

ORDレコード
ord-769abdb1e1c04291aba9f614092bf047
出典データセット
uspto-grants-2010_09
特許番号
US07790756B2

反応ノート

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