Acetic Acid → Ziprasidone Hydrochloride

HRID 1711975

反応式

HRID 1711975 の反応式
[CH:1]1[CH:2]=[CH:3][C:4]2[S:9][N:8]=[C:7]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]4[CH:19]=[C:20]5[CH2:28][C:26](=[O:27])[NH:25][C:21]5=[CH:22][C:23]=4[Cl:24])[CH2:12][CH2:11]3)[C:5]=2[CH:6]=1.C(O)(=O)C.[ClH:33].O>C(O)(C)C>[CH:1]1[CH:2]=[CH:3][C:4]2[S:9][N:8]=[C:7]([N:10]3[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][C:18]4[CH:19]=[C:20]5[CH2:28][C:26](=[O:27])[NH:25][C:21]5=[CH:22][C:23]=4[Cl:24])[CH2:14][CH2:15]3)[C:5]=2[CH:6]=1.[ClH:33]

参加物

6

反応物 4

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 962WaterHCID 60854Ziprasidone

生成物 1

HCID 219099Ziprasidone Hydrochloride

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

反応条件

温度
47.5 °C

実験手順

Ziprasidone (5 g) and 50 mL of acetic acid were placed into a round bottom flask and heated to 45-50° C. Added was 25 mL of aqueous hydrochloric acid slowly to the mixture over 20 min. Then the reaction mixture was refluxed. Water (10 mL) was added, followed by addition of 50 mL of Isopropanol. The reaction mass was cooled to 50° C. and distilled off the solvent completely under vacuum. The material formed was scratched from the flask.

後処理

  1. additionAdded
  2. customover 20 min
  3. temperatureThen the reaction mixture was refluxed
  4. temperatureThe reaction mass was cooled to 50° C.
  5. distillationdistilled off the solvent completely under vacuum
  6. customThe material formed

出典と根拠

ORDレコード
ord-36d1abf674464e1b903451edb8e95ec6
出典データセット
uspto-grants-2010_09
特許番号
US07790886B2

関連ノート

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