Trifluoroacetic acid → 3-(Hydroxymethyl)azetidine trifluoroacetate
反応式
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[OH:8][CH2:9][CH:10]1[CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11]1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[OH:8][CH2:9][CH:10]1[CH2:13][NH:12][CH2:11]1参加物
3
実験手順
Trifluoroacetic acid (0.413 ml) was added to tert-butyl 3-(hydroxymethyl)azetidine-1-carboxylate (125 mg) with cooling in an ice bath, followed by stirring at the same temperature for 30 minutes. Then the reaction mixture was stirred at room temperature for 1.5 hours. The reaction mixture was concentrated to give a crude product of the title compound (209.8 mg) as a yellow oil.
後処理
- temperaturewith cooling in an ice bath
- stirringThen the reaction mixture was stirred at room temperature for 1.5 hours
- concentrationThe reaction mixture was concentrated
出典と根拠
- ORDレコード
- ord-a3848cf7b5da400ea19765646c790181
- 出典データセット
- uspto-grants-2010_09
- 特許番号
- US07790885B2
反応ノート
読み込み中…