HCID 86626004、化合物 → 4-(5,6-Dihydro-8H-imidazo(5,1-c)(1,4)oxazin-8-yl)benzonitrile
反応式
CS(O[CH2:6][CH2:7][O:8][CH:9]([C:15]1[CH:20]=[CH:19][C:18]([C:21]#[N:22])=[CH:17][CH:16]=1)[C:10]1[NH:11][CH:12]=[N:13][CH:14]=1)(=O)=O>C(#N)C>[CH:14]1[N:13]=[CH:12][N:11]2[CH2:6][CH2:7][O:8][CH:9]([C:15]3[CH:20]=[CH:19][C:18]([C:21]#[N:22])=[CH:17][CH:16]=3)[C:10]=12参加物
3
実験手順
A solution of 1.20 mmol of 2-[(4-cyanophenyl)-(3H-imidazol-4-yl)methoxy]ethyl methanesulphonate in 10 ml of acetonitrile is heated to reflux for 24 hours. The reaction mixture is cooled to room temperature and evaporated. The title compound is obtained as a white solid from the residue by flash chromatography (SiO2 60F). Rf=0.14 (dichloromethane -2M ammonia in ethanol 95:5); Rt=4.29.
後処理
- temperatureto reflux for 24 hours
- customevaporated
出典と根拠
- ORDレコード
- ord-efbaa6e3a15d401294c9915aa4bef7a2
- 出典データセット
- uspto-grants-2010_09
- 特許番号
- US07795253B2
反応ノート
読み込み中…