Hydrazine hydrate (1:1) → 5-({[Tert-butyl(dimethyl)silyl]oxy}methyl)isoxazole-3-carbohydrazide
反応式
C([O:3][C:4]([C:6]1[CH:10]=[C:9]([CH2:11][O:12][Si:13]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14])[O:8][N:7]=1)=O)C.O.[NH2:21][NH2:22]>C(O)C>[Si:13]([O:12][CH2:11][C:9]1[O:8][N:7]=[C:6]([C:4]([NH:21][NH2:22])=[O:3])[CH:10]=1)([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14]参加物
4
反応条件
- 温度
- 60 °C
実験手順
A mixture of ethyl-5-({[tert-butyl(dimethylsilyl)]oxy}methyl)isoxazole-3-carboxylate (1.68 g, 5.9 mmol) and hydrazine hydrate (44 g, 8.8 mmol) in ethanol (30 mL) is heated to 60° C. for 4 hours. The mixture is cooled to room temperature and the solvents are removed in vacuo to yield 5-({[tert-butyl(dimethyl)silyl]oxy}methyl)isoxazole-3-carbohydrazide as orange crystals.