6-Benzyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one → 5,6,7,8-Tetrahydro-1,6-naphthyridin-2(1H)-one

HRID 1713119ノート

反応式

HRID 1713119 の反応式
C([N:8]1[CH2:17][CH2:16][C:15]2[NH:14][C:13](=[O:18])[CH:12]=[CH:11][C:10]=2[CH2:9]1)C1C=CC=CC=1>CCO.[OH-].[OH-].[Pd+2]>[NH:14]1[C:15]2[CH2:16][CH2:17][NH:8][CH2:9][C:10]=2[CH:11]=[CH:12][C:13]1=[O:18]

参加物

4

反応物 1

HCID 223351456-Benzyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one

生成物 1

HCID 210711895,6,7,8-Tetrahydro-1,6-naphthyridin-2(1H)-one

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒

実験手順

To a solution of 6-benzyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one (400 mg, 1.66 mmol) in EtOH (30 mL) is added 20% Pd(OH)2/C (20 mg) and the mixture is hydrogenated at 50 psi at rt overnight. The catalyst is filtered and the filtrate is concentrated to give the title compound as a light yellow solid. MS (M+1): 151.1

後処理

  1. filtrationThe catalyst is filtered
  2. concentrationthe filtrate is concentrated

出典と根拠

ORDレコード
ord-515b6b48b422430291278b818b69228a
出典データセット
uspto-grants-2010_09
特許番号
US07795262B2

反応ノート

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