HCID 67454416、化合物 → HCID 67456175、化合物

HRID 1713265ノート

反応式

HRID 1713265 の反応式
C([O:8][C:9]1[CH:10]=[C:11]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[CH:17][CH:16]=2)[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>C(O)C.O1CCCC1.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][NH:22][C:23](=[O:29])[O:24][C:25]([CH3:27])([CH3:26])[CH3:28])=[CH:17][CH:16]=2)[CH:12]=[CH:13][CH:14]=1

参加物

4

反応物 1

HCID 67454416HCID 67454416、化合物

生成物 1

HCID 67456175HCID 67456175、化合物収率 82%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 21873804Tetrahydrofuran ethanol溶媒

反応条件

温度
30 °C

実験手順

To a solution of tert-butyl N-(3′-bezyloxy-biphenyl-4-ylmethyl)carbamate (1.16 g) in ethanol/tetrahydrofuran (4/1, 30 mL) was added 10% palladium-on carbon (55.4 wt % H2O, 0.520 g), and the resulting mixture was stirred at 30° C. for 5 hours under a hydrogen atmosphere. The insoluble material was filtered out and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate=5/2) to give the title compound (0.731 g).

後処理

  1. filtrationThe insoluble material was filtered out
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate=5/2)

出典と根拠

ORDレコード
ord-55b5c87d9b5e4a63b67cc51314548f97
出典データセット
uspto-grants-2010_09
特許番号
US07795236B2

反応ノート

読み込み中…