8-(3'-Benzyloxybiphenyl-4-ylmethylamino)adenosine → 8-(3'-Hydroxybiphenyl-4-ylmethylamino)adenosine

HRID 1713327ノート

反応式

HRID 1713327 の反応式
C([O:8][C:9]1[CH:10]=[C:11]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][NH:22][C:23]3[N:24]([C:34]4[N:35]=[CH:36][N:37]=[C:38]([NH2:41])[C:39]=4[N:40]=3)[C@@H:25]3[O:33][C@H:30]([CH2:31][OH:32])[C@@H:28]([OH:29])[C@H:26]3[OH:27])=[CH:17][CH:16]=2)[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>[Pd].CO>[OH:8][C:9]1[CH:10]=[C:11]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][NH:22][C:23]3[N:24]([C:34]4[N:35]=[CH:36][N:37]=[C:38]([NH2:41])[C:39]=4[N:40]=3)[C@@H:25]3[O:33][C@H:30]([CH2:31][OH:32])[C@@H:28]([OH:29])[C@H:26]3[OH:27])=[CH:17][CH:16]=2)[CH:12]=[CH:13][CH:14]=1

参加物

4

反応物 1

HCID 594603638-(3'-Benzyloxybiphenyl-4-ylmethylamino)adenosine

生成物 1

HCID 594604808-(3'-Hydroxybiphenyl-4-ylmethylamino)adenosine収率 93.9%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 8-(3′-benzyloxybiphenyl-4-ylmethyl-amino)adenosine (0.103 g) and 10% palladium on carbon (55.4 wt % H2O, 0.047 g) in methanol (7.4 mL) was stirred at room temperature for 17.5 hours under a hydrogen atmosphere. The insoluble material was filtered out and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: dichloromethane/methanol=8/1 to 6/1) to give the title compound (0.081 g).

後処理

  1. filtrationThe insoluble material was filtered out
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe residue was purified by column chromatography on silica gel (eluent: dichloromethane/methanol=8/1 to 6/1)

出典と根拠

ORDレコード
ord-23317bac68204da2add70d1d0e5779c5
出典データセット
uspto-grants-2010_09
特許番号
US07795236B2

反応ノート

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