3-amino-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide → 6-Dimethylsulfamoyl-pyrazolo[1,5-a]pyridine-3-carboxylic acid [2-methyl-5-(3-trifluoromethyl-phenylcarbamoyl)-phenyl]-amide

HRID 1713389ノート

反応式

HRID 1713389 の反応式
[CH3:1][N:2]([CH3:18])[S:3]([C:6]1[CH:7]=[CH:8][C:9]2[N:10]([N:12]=[CH:13][C:14]=2[C:15](Cl)=[O:16])[CH:11]=1)(=[O:5])=[O:4].[NH2:19][C:20]1[CH:21]=[C:22]([CH:36]=[CH:37][C:38]=1[CH3:39])[C:23]([NH:25][C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:34])[F:33])[CH:27]=1)=[O:24]>N1C=CC=CC=1>[CH3:39][C:38]1[CH:37]=[CH:36][C:22]([C:23](=[O:24])[NH:25][C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:33])([F:34])[F:35])[CH:27]=2)=[CH:21][C:20]=1[NH:19][C:15]([C:14]1[CH:13]=[N:12][N:10]2[CH:11]=[C:6]([S:3](=[O:5])(=[O:4])[N:2]([CH3:18])[CH3:1])[CH:7]=[CH:8][C:9]=12)=[O:16]

参加物

4

反応物 2

HCID 201196943-amino-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamideHCID 866251176-Dimethylsulfamoyl-pyrazolo[1,5-a]pyridine-3-carbonyl chloride

生成物 1

HCID 166620846-Dimethylsulfamoyl-pyrazolo[1,5-a]pyridine-3-carboxylic acid [2-methyl-5-(3-trifluoromethyl-phenylcarbamoyl)-phenyl]-amide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

6-Dimethylsulfamoyl-pyrazolo[1,5-a]pyridine-3-carbonyl chloride (200 mg, 0.35 mmol) and 3-amino-4-methyl-N-(3-trifluoromethyl-phenyl)-benzamide are reacted in 2 ml dry pyridine at r.t. for 18 hrs. The solvent is removed under reduced pressure. The product is isolated by automated column chromatography and is dried at the high vacuum pump, yielding the title compound as a white solid.

後処理

  1. customThe solvent is removed under reduced pressure
  2. customThe product is isolated by automated column chromatography
  3. customis dried at the high vacuum pump

出典と根拠

ORDレコード
ord-3ef696b5e4514f45914c00dc16067d8a
出典データセット
uspto-grants-2010_09
特許番号
US07795273B2

反応ノート

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