3-Methyl-1,2-dihydroisoquinolin-1-one → 3-Methyl-5,6,7,8-tetrahydro-2H-isoquinolin-1-one

HRID 1713395ノート

反応式

HRID 1713395 の反応式
[CH3:1][C:2]1[NH:3][C:4](=[O:12])[C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2>C(O)(=O)C.[Pt](=O)=O>[CH3:1][C:2]1[NH:3][C:4](=[O:12])[C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:10]=2[CH:11]=1

参加物

4

反応物 1

HCID 32444773-Methyl-1,2-dihydroisoquinolin-1-one

生成物 1

HCID 123314983-Methyl-5,6,7,8-tetrahydro-2H-isoquinolin-1-one収率 83%

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 176Acetic Acid溶媒

実験手順

8.45 g (53 mmol) of 3-methyl-2H-isoquinolin-1-one are dissolved in 80 ml of glacial acetic acid and, after addition of 168 mg (0.74 mmol) of platinum(IV) oxide, hydrogenated under 5 bar at RT for 8 h. The suspension is filtered and concentrated and the residue is recrystallized from methanol. 7.15 g (83%) of a colorless oil are obtained.

後処理

  1. filtrationThe suspension is filtered
  2. concentrationconcentrated
  3. customthe residue is recrystallized from methanol

出典と根拠

ORDレコード
ord-a89b661876994b46a6e0d2618adf0d8c
出典データセット
uspto-grants-2010_09
特許番号
US07795278B2

反応ノート

読み込み中…