{5-[4-(3-Dimethylamino-propoxy)-phenyl]-thiazol-2-yl}phenyl-amine → [4-(3-Dimethylamino-propoxy)-phenyl]-(5-thiophen-3-yl-thiazol-2-yl)-amine

HRID 1713655

反応式

HRID 1713655 の反応式
[CH3:1][N:2]([CH3:25])[CH2:3][CH2:4][CH2:5]OC1C=CC(C2SC(NC3C=CC=CC=3)=NC=2)=CC=1.[S:26]1[CH:30]=[CH:29][C:28]([C:31]2[S:35][C:34]([NH:36][C:37]3[CH:42]=[CH:41][C:40]([OH:43])=[CH:39][CH:38]=3)=[N:33][CH:32]=2)=[CH:27]1>C(Cl)Cl.CO>[CH3:1][N:2]([CH3:25])[CH2:3][CH2:4][CH2:5][O:43][C:40]1[CH:41]=[CH:42][C:37]([NH:36][C:34]2[S:35][C:31]([C:28]3[CH:29]=[CH:30][S:26][CH:27]=3)=[CH:32][N:33]=2)=[CH:38][CH:39]=1

参加物

4

反応物 2

HCID 11245147{5-[4-(3-Dimethylamino-propoxy)-phenyl]-thiazol-2-yl}phenyl-amineHCID 11288835HCID 11288835、化合物

生成物 1

HCID 11405705[4-(3-Dimethylamino-propoxy)-phenyl]-(5-thiophen-3-yl-thiazol-2-yl)-amine

試薬・触媒・溶媒 1

HCID 21226129Dichloromethane methanol溶媒

実験手順

The title compound is prepared as described in Example 8 for {5-[4-(3-dimethylamino-propoxy)-phenyl]-thiazol-2-yl}phenyl-amine but starting from 4-(5-thiophen-3-yl-thiazol-2-yl-amino)-phenol (Example 12). Title compound: ES-MS: 360.0 [M+H]+; single peak at tR=6.16 min (System 1); Rf=0.12 (CH2Cl2/MeOH, 85/15).

後処理

  1. customThe title compound is prepared

出典と根拠

ORDレコード
ord-3acdd498a2dc4dac8356a25ccf5bf1d4
出典データセット
uspto-grants-2010_09
特許番号
US07795288B2

関連ノート

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