反応式
[F:1][C:2]([F:15])([F:14])[C:3]([NH:5][CH:6]([CH2:10][CH2:11][CH2:12][CH3:13])C(O)=O)=[O:4].C(Cl)(=O)[C:17]([Cl:19])=[O:18]>ClCCl.CN(C)C=O>[F:15][C:2]([F:1])([F:14])[C:3]([NH:5][CH2:6][CH2:10][CH2:11][CH2:12][CH2:13][C:17]([Cl:19])=[O:18])=[O:4]参加物
5
反応条件
- 温度
- 0 °C
実験手順
735 mg(3 mmol) (2,2,2-trifluoro-acetylamino)-hexanoic acid were dissolved in 5 mL dried dichloromethane and stirred under argon flux at 0° C. Then, 0.6 mL (6.6 mmol) oxalyl chloride were added dropwise at 0° C., a few drops of dried dimethylformamide were also added dropwise which lead to gas development and yellow colouring of the previously white mixture. The mixture, was stirred at room temperature for 70 min. Then the mixture was repeatedly evaporated with dichloromethane. The crude product was used directly in the next step.
後処理
- stirringThe mixture, was stirred at room temperature for 70 min
- customThen the mixture was repeatedly evaporated with dichloromethane
出典と根拠
- ORDレコード
- ord-b39c693e046641f98956833f6e0466d1
- 出典データセット
- uspto-grants-2010_09
- 特許番号
- US07795423B2
関連ノート
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