Formaldehyde → (2,2-Dimethyl-propyl)-methyl-[2-methyl-2-(4-nitro-imidazol-1-yl)-Propyl]-amine

HRID 1714282ノート

反応式

HRID 1714282 の反応式
[CH3:1][C:2]([CH3:18])([CH3:17])[CH2:3][NH:4][CH2:5][C:6]([CH3:16])([N:8]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[N:10]=[CH:9]1)[CH3:7].[CH2:19]=O>C(O)=O>[CH3:1][C:2]([CH3:18])([CH3:17])[CH2:3][N:4]([CH3:19])[CH2:5][C:6]([CH3:16])([N:8]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[N:10]=[CH:9]1)[CH3:7]

参加物

4

反応物 2

HCID 712FormaldehydeHCID 671640862,2-dimethyl-N-[2-methyl-2-(4-nitro-1H-imidazol-1-yl)propyl]propan-1-amine

生成物 1

HCID 67164483(2,2-Dimethyl-propyl)-methyl-[2-methyl-2-(4-nitro-imidazol-1-yl)-Propyl]-amine

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

(2,2-Dimethyl-propyl)-[2-methyl-2-(4-nitro-imidazol-1-yl)-propyl]-amine was treated with formalin and formic acid at 85° C. for 5 h, quenched with aqueous sodium bicarbonate, extracted with methylene chloride, dried, concentrated, and the resultant residue purified by chromatography to afford the title compound: H1 NMR (400 MHz, CDCl3) 0.74 (s, 9H), 1.52 (s, 6H), 2.2 (s, 2H), 2.8 (s, 2H), 7.6 (s, 1H), 7.9 (s, 1H); MS m/z 255.3 (M+1).

後処理

  1. customquenched with aqueous sodium bicarbonate
  2. extractionextracted with methylene chloride
  3. customdried
  4. concentrationconcentrated
  5. customthe resultant residue purified by chromatography

出典と根拠

ORDレコード
ord-598e2c72c6d0437fa430f2fb5505193b
出典データセット
uspto-grants-2010_09
特許番号
US07795447B2

反応ノート

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