Water → HCID 802571、化合物
反応式
[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]1[S-:13].[K+].[CH3:15]I.O>CN(C)C=O>[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]1[S:13][CH3:15]参加物
5
実験手順
To a solution 209 mg of potassium 3-amino-3H-quinazolin-4-one-2-thiolate in 5 ml of dimethylformamide, 141 mg of methyl iodide was added, and stirred for 20 minutes at room temperature. Water was added to the solution, followed by extraction with ethyl acetate and drying over anhydrous magnesium sulfate. Distilling the solvent off under reduced pressure, 161 mg (86%) of 3-amino-2-methylthio-3H-quinazolin-4-one was obtained.
後処理
- extractionfollowed by extraction with ethyl acetate
- dry with materialdrying over anhydrous magnesium sulfate
- distillationDistilling the solvent off under reduced pressure
出典と根拠
- ORDレコード
- ord-78a64271e5e54bdf9227a2a1138c65e4
- 出典データセット
- uspto-grants-2010_09
- 特許番号
- US07799775B2
反応ノート
読み込み中…