Hydrogen Bromide → 3-Amino-2-hydroxy-4-(2-thienyl)butanamide
反応式
Br.C1(COC(=O)[NH:11][CH:12]([CH2:18][C:19]2[S:20][CH:21]=[CH:22][CH:23]=2)[CH:13]([OH:17])[C:14]([NH2:16])=[O:15])C=CC=CC=1>C(O)(=O)C>[NH2:11][CH:12]([CH2:18][C:19]1[S:20][CH:21]=[CH:22][CH:23]=1)[CH:13]([OH:17])[C:14]([NH2:16])=[O:15]参加物
4
実験手順
70 ml of 30% HBr in glacial acetic acid were added to 11 g of phenylmethyl[3-amino-2-hydroxy-3-oxo-1-(2-thienylmethyl)propyl]carbamate (29.66 mmol) in 30 ml of glacial acetic acid. After about 2 hours, the mixture was concentrated and the resulting residue was stirred firstly with cyclohexane and then with dichloromethane. 7.8 g of the title compound were obtained as hydrobromide.
後処理
- concentrationthe mixture was concentrated
出典と根拠
- ORDレコード
- ord-44d0189bf93a47d4ad601bf92405613a
- 出典データセット
- uspto-grants-2010_09
- 特許番号
- US07799809B2
反応ノート
読み込み中…