1,1'-Carbonyldiimidazole → HCID 59323901、化合物
反応式
[NH2:1][C:2]1[S:3][C:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=[O:16])[CH3:15])=[C:10]([F:17])[CH:9]=2)=[C:5]([CH3:7])[N:6]=1.[CH:18]1[N:22]=[CH:21][N:20]([C:23](N2C=NC=C2)=[O:24])[CH:19]=1>C(Cl)Cl>[C:14]([C:11]1[CH:12]=[CH:13][C:8]([C:4]2[S:3][C:2]([NH:1][C:23]([N:20]3[CH:19]=[CH:18][N:22]=[CH:21]3)=[O:24])=[N:6][C:5]=2[CH3:7])=[CH:9][C:10]=1[F:17])(=[O:16])[CH3:15]参加物
4
実験手順
Dry DCM (10 ml) is added to 1-[4-(2-amino-4-methyl-thiazol-5-yl)-2-fluoro-phenyl]-ethanone (0.25 g, 1.0 mmol) and CDI (0.259 g, 1.6 mmol) and the mixture is heated at reflux for 4 hours. The resulting suspension is filtered and dried under vacuum to afford the title compound.
後処理
- temperaturethe mixture is heated
- temperatureat reflux for 4 hours
- filtrationThe resulting suspension is filtered
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-a94a4c45cdae427f930bcdf23140a05e
- 出典データセット
- uspto-grants-2010_09
- 特許番号
- US07799810B2
反応ノート
読み込み中…