Methyl iodide → HCID 59467505、化合物

反応式

[Cl:1][C:2]1[C:7]([NH:8][C:9](=[O:16])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[C:17](=O)([O-])[O-].[K+].[K+].CI>C(O)C>[Cl:1][C:2]1[C:7]([N:8]([CH3:17])[C:9](=[O:16])[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[CH:6][CH:5]=[CH:4][N:3]=1

参加物

実験手順

4.6 g N-(2-chloro-pyridin-3-yl)-benzamide (20 mmol), 8.2 g potassium carbonate (K2CO3) (60 mmol), and 50 mL ethanol were added and stirred in a round-bottomed flask. 4.2 g methyl iodide (MeI) (30 mmol) was then added and reacted for 24 hr. After cooling to room temperature, the reaction was quenched by water. After extraction three times by ethyl acetate, removal of water by magnesium sulphate (MgSO4), concentration, and purification by column, 4.18 g white solid was obtained, with a yield of 85%.