4-Fluorobenzenesulfonyl chloride → N-(2-Bromo-pyridin-3-yl)-4-fluoro-benzenesulfonamide

HRID 1716281ノート

反応式

HRID 1716281 の反応式
[NH2:1][C:2]1[C:3]([Br:8])=[N:4][CH:5]=[CH:6][CH:7]=1.[F:9][C:10]1[CH:15]=[CH:14][C:13]([S:16](Cl)(=[O:18])=[O:17])=[CH:12][CH:11]=1>ClCCl.N1C=CC=CC=1>[Br:8][C:3]1[C:2]([NH:1][S:16]([C:13]2[CH:14]=[CH:15][C:10]([F:9])=[CH:11][CH:12]=2)(=[O:18])=[O:17])=[CH:7][CH:6]=[CH:5][N:4]=1

参加物

5

反応物 2

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 6428163-Amino-2-bromopyridine

生成物 1

HCID 86619934N-(2-Bromo-pyridin-3-yl)-4-fluoro-benzenesulfonamide

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of 3-amino-2-bromo-pyridine (0.4 g, 2.3 mmol) in dichloromethane (4 ml) and pyridine (4 ml) was added 4-fluoro-benzenesulfonylchloride (0.45 g, 2.3 mmol) in one portion. The mixture was stirred overnight. The mixture was diluted with dichloromethane and washed with saturated NaCl solution. The organic layer was dried over sodium sulfate and concentrated. The crude product was purified through chromatography (2-5% EtOAc in dichloromethane). MS 331.8 (M+H)+

後処理

  1. washwashed with saturated NaCl solution
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. concentrationconcentrated
  4. customThe crude product was purified through chromatography (2-5% EtOAc in dichloromethane)

出典と根拠

ORDレコード
ord-7835a80f5e544a4eaccc53c5708fcdb0
出典データセット
uspto-grants-2010_09
特許番号
US07803793B2

反応ノート

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