4-azidomethyl-5-methyl-2-phenyl-1H-imidazole → C-(5-methyl-2-phenyl-1H-imidazol-4-yl)-methylamine
反応式
[N:1]([CH2:4][C:5]1[N:6]=[C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[NH:8][C:9]=1[CH3:10])=[N+]=[N-]>C(O)C.[Pd]>[CH3:10][C:9]1[NH:8][C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:6][C:5]=1[CH2:4][NH2:1]参加物
4
実験手順
To solution of 4-azidomethyl-5-methyl-2-phenyl-1H-imidazole (1.22 g) in ethanol (50 ml) was added 10% Pd/C (0.10 g). The reaction mixture was hydrogenated at room temperature and 1.1 bar for 30 minutes, the catalyst was filtered off over a pad of celite. The filtrate was evaporated to dryness under high vacuum to obtain C-(5-methyl-2-phenyl-1H-imidazol-4-yl)-methylamine (1.06 g) as a light yellow foam which was sufficiently pure to be used directly in the next step.
後処理
- customwas hydrogenated at room temperature
- filtrationthe catalyst was filtered off over a pad of celite
- customThe filtrate was evaporated to dryness under high vacuum
出典と根拠
- ORDレコード
- ord-84deed8f53c849b6ae7538afaab99955
- 出典データセット
- uspto-grants-2010_09
- 特許番号
- US07803819B2
反応ノート
読み込み中…