Ethyl Bromide → 3-ethoxy-N-ethyl-4-nitrobenzamide

HRID 1717328ノート

反応式

HRID 1717328 の反応式
[CH2:1]([NH:3][C:4](=[O:15])[C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[C:7]([OH:14])[CH:6]=1)[CH3:2].[CH2:16](Br)[CH3:17].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:16]([O:14][C:7]1[CH:6]=[C:5]([CH:10]=[CH:9][C:8]=1[N+:11]([O-:13])=[O:12])[C:4]([NH:3][CH2:1][CH3:2])=[O:15])[CH3:17]

参加物

5

反応物 3

HCID 6332Ethyl BromideHCID 11430Potassium CarbonateHCID 21029708N-ethyl-3-hydroxy-4-nitrobenzamide

生成物 1

HCID 685151263-ethoxy-N-ethyl-4-nitrobenzamide収率 30%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of N-ethyl-3-hydroxy-4-nitrobenzamide (2.10 g) obtained in Example 131a) in acetone (100 ml) were added ethyl bromide (0.75 ml) and potassium carbonate (1.38 g), and the reaction mixture was heated under reflux overnight. The reaction mixture was allowed to cool to room temperature and the solvent was evaporated under reduced pressure. Ethyl acetate and water were added to the residue. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound as a pale-brown solid (0.72 g, 30%).

後処理

  1. temperaturethe reaction mixture was heated
  2. temperatureunder reflux overnight
  3. customthe solvent was evaporated under reduced pressure
  4. additionEthyl acetate and water were added to the residue
  5. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  6. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-9ead7259b1fd45b5bfccfd41b0cf1cd1
出典データセット
uspto-grants-2010_09
特許番号
US07803822B2

反応ノート

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