Water → 1-[2-ethoxy-4-[(ethylamino)carbonyl]phenyl]-1H-1,2,3-Triazole-4-carboxylic acid

HRID 1717332ノート

反応式

HRID 1717332 の反応式
[CH2:1]([O:3][C:4]1[CH:9]=[C:8]([C:10]([NH:12][CH2:13][CH3:14])=[O:11])[CH:7]=[CH:6][C:5]=1[N:15]1[CH:19]=[C:18]([C:20]([O:22]CC)=[O:21])[N:17]=[N:16]1)[CH3:2].[OH-].[Na+].O>C(O)C>[CH2:1]([O:3][C:4]1[CH:9]=[C:8]([C:10]([NH:12][CH2:13][CH3:14])=[O:11])[CH:7]=[CH:6][C:5]=1[N:15]1[CH:19]=[C:18]([C:20]([OH:22])=[O:21])[N:17]=[N:16]1)[CH3:2]

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 68516073ethyl 1-{2-ethoxy-4-[(ethylamino)carbonyl]phenyl}-1H-1,2,3-triazole-4-carboxylate

生成物 1

HCID 685156141-[2-ethoxy-4-[(ethylamino)carbonyl]phenyl]-1H-1,2,3-Triazole-4-carboxylic acid収率 77.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

To a solution of ethyl 1-{2-ethoxy-4-[(ethylamino)carbonyl]phenyl}-1H-1,2,3-triazole-4-carboxylate (0.51 g) obtained in Example 131e) in ethanol (8 ml) was added 8N aqueous sodium hydroxide solution (0.39 ml), and the mixture was stirred at room temperature for 5 hr. Water was added to the reaction mixture, and ethanol was evaporated under reduced pressure. Water was added to the obtained aqueous solution and the mixture was washed with ethyl acetate. 1N Hydrochloric acid was added to acidify the aqueous solution. The deposited precipitate was collected by filtration, washed with water and air-dried to give the title compound as a white powder (0.36 g, 76%).

後処理

  1. customwas evaporated under reduced pressure
  2. additionWater was added to the obtained aqueous solution
  3. washthe mixture was washed with ethyl acetate
  4. addition1N Hydrochloric acid was added
  5. filtrationThe deposited precipitate was collected by filtration
  6. washwashed with water
  7. customair-dried

出典と根拠

ORDレコード
ord-ad996ebaa3164c459bba85c107a38987
出典データセット
uspto-grants-2010_09
特許番号
US07803822B2

反応ノート

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