Methanol → Methyl 2-(bromomethyl)-6-methylbenzoate

HRID 1717442ノート

反応式

HRID 1717442 の反応式
[Br:1][CH2:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:4]=1[C:5](Br)=[O:6].[CH3:13][OH:14]>CCCCCCC>[Br:1][CH2:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:4]=1[C:5]([O:14][CH3:13])=[O:6]

参加物

4

反応物 2

HCID 887MethanolHCID 219803072-(Bromomethyl)-6-methylbenzoyl bromide

生成物 1

HCID 10263795Methyl 2-(bromomethyl)-6-methylbenzoate収率 98.8%

試薬・触媒・溶媒 1

HCID 8900Heptane溶媒

実験手順

200 g (240 mmol) of 2-bromomethyl-6-methylbenzoyl bromide solution (35% solution in heptane) are added to 400 ml of methanol. After stirring at RT for one hour, 400 ml of n-heptane are added. The solution is washed successively with 600 ml of sat. sodium hydrogencarbonate solution and three times with 200 ml each time of water. Subsequently, the solvent is removed fully under reduced pressure. 98.8% of methyl 2-bromomethyl-6-methylbenzoate is obtained as a colorless oil having a purity of 80% (included in the yield) and having a molecular weight of 241.99 (C10H11BrO2); MS (ESI): 243.1 [M+H+].

後処理

  1. washThe solution is washed successively with 600 ml of sat. sodium hydrogencarbonate solution and three times with 200 ml each time of water
  2. customSubsequently, the solvent is removed fully under reduced pressure

出典と根拠

ORDレコード
ord-a454f6bc4218401bb442a2697f33111c
出典データセット
uspto-grants-2010_09
特許番号
US07803950B2

反応ノート

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