1-(3-(Bromomethyl)phenyl)ethan-1-one → Ethyl 2-(3-acetylbenzyl)-3-oxobutanoate

HRID 1718277ノート

反応式

HRID 1718277 の反応式
[C:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7]Br)(=[O:3])[CH3:2].[Na].[C:13]([O:19][CH2:20][CH3:21])(=[O:18])[CH2:14][C:15]([CH3:17])=[O:16]>O1CCCC1>[C:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7][CH:14]([C:15](=[O:16])[CH3:17])[C:13]([O:19][CH2:20][CH3:21])=[O:18])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 154798071-(3-(Bromomethyl)phenyl)ethan-1-oneHCID 87089461Ethyl acetoacetatesodium salt

生成物 1

HCID 57460081Ethyl 2-(3-acetylbenzyl)-3-oxobutanoate収率 49.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 3-acetylbenzyl bromide (4 g) and ethyl acetoacetate sodium salt (3.42 g) in tetrahydrofuran (50 mL) was stirred for 12 hr. The insoluble material was filtered off and the filtrate was concentrated. The residue was purified by silica gel column chromatography to give the title compound (2.42 g, 49%) as a colorless viscous oil.

後処理

  1. filtrationThe insoluble material was filtered off
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-42a260483dfb47128689a80a7519fc03
出典データセット
uspto-grants-2010_09
特許番号
US07803940B2

反応ノート

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