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Sodium periodate → [4-(2-{[Tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylpropoxy)phenyl]boronic acid

HRID 1718974
ノート
印刷プレビュー

反応式

HRID 1718974 の反応式
[C:1]([Si:5]([O:8][CH:9]([CH3:29])[C:10]([CH3:28])([O:12][C:13]1[CH:18]=[CH:17][C:16]([B:19]2[O:23]C(C)(C)C(C)(C)[O:20]2)=[CH:15][CH:14]=1)[CH3:11])([CH3:7])[CH3:6])([CH3:4])([CH3:3])[CH3:2].I([O-])(=O)(=O)=O.[Na+]>Cl.O1CCCC1.O>[Si:5]([O:8][CH:9]([CH3:29])[C:10]([CH3:28])([CH3:11])[O:12][C:13]1[CH:18]=[CH:17][C:16]([B:19]([OH:20])[OH:23])=[CH:15][CH:14]=1)([C:1]([CH3:4])([CH3:3])[CH3:2])([CH3:7])[CH3:6]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 2

HCID 23667635Sodium periodateHCID 57460957tert-Butyl{1,2-dimethyl-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]propoxy}dimethylsilane

生成物 1

HCID 57460958[4-(2-{[Tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylpropoxy)phenyl]boronic acid

試薬・触媒・溶媒 3

HCID 313Hydrochloric Acid溶媒HCID 962Water溶媒2 回
HCID 8028
Tetrahydrofuran
溶媒

実験手順

tert-Butyl{1,2-dimethyl-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]propoxy}dimethylsilane (5.8 g) was dissolved in 1 M hydrochloric acid (20 mL)-tetrahydrofuran (20 mL)-water (20 mL), sodium periodate (5.9 g) was added, and the mixture was stirred at room temperature for 3 hr. The reaction mixture was diluted with water, extracted with ethyl acetate, washed with 1 M hydrochloric acid, saturated aqueous sodium hydrogen carbonate solution and saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the title compound as a pale-yellow solid (1.1 g, 23%).

後処理

  1. additionwas added
  2. extractionextracted with ethyl acetate
  3. washwashed with 1 M hydrochloric acid, saturated aqueous sodium hydrogen carbonate solution and saturated brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-840bd34b17ad48f998e3b52dd787ac2c
出典データセット
uspto-grants-2010_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07803940B2

反応ノート

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