Hydrogen Bromide → 3-amino-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrobromide

HRID 1719116ノート

反応式

HRID 1719116 の反応式
C(OC([NH:11][CH:12]1[C:18](=[O:19])[NH:17][C:16]2[CH:20]=[CH:21][CH:22]=[CH:23][C:15]=2[S:14][CH:13]1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=O)C1C=CC=CC=1.CCOCC.[BrH:35]>C(O)(=O)C>[BrH:35].[NH2:11][CH:12]1[C:18](=[O:19])[NH:17][C:16]2[CH:20]=[CH:21][CH:22]=[CH:23][C:15]=2[S:14][CH:13]1[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

参加物

5

反応物 3

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 134905083-benzyloxycarbonylamino-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

生成物 1

HCID 199935893-amino-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrobromide

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

5.4 g of the compound obtained in Example 2 was dissolved in a 25% solution of hydrogen bromide in acetic acid. After the lapse of 2 hours, 15 ml of acetic acid was added to the solution and the resulting mixture was stirred for an hour. After the addition of ether, the precipitated crystals were separated by filtration and washed with ether to obtain 4.0 g of the desired compound.

後処理

  1. customthe precipitated crystals were separated by filtration
  2. washwashed with ether

出典と根拠

ORDレコード
ord-7288c878400646f29737b69e45b98104
出典データセット
uspto-grants-1985_09
特許番号
US04539150

反応ノート

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