Methanesulfenylchloride → 1-[(Chloromethoxy)methyl]naphthalene

HRID 1719234ノート

反応式

HRID 1719234 の反応式
S(Cl)(Cl)(=O)=O.C1C2C(=CC=CC=2)C=CC=1.[C:16]1([CH2:26][O:27][CH2:28]SC)[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=[CH:18][CH:17]=1.CS[Cl:33]>ClCCl>[Cl:33][CH2:28][O:27][CH2:26][C:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=[CH:18][CH:17]=1

参加物

5

反応物 3

HCID 138595MethanesulfenylchlorideHCID 15650475Methylthiomethyl 1-naphthylmethyl etherHCID 22556242HCID 22556242、化合物

生成物 1

HCID 134082881-[(Chloromethoxy)methyl]naphthalene

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

1-Chloromethyloxymethyl)naphthalene Sulfuryl chloride (12 mmol) in dry dichloromethane (20 mmol) was added dropwise with stirring to a solution of methylthiomethyl 1-naphthylmethyl ether (12 mmol) in dry dichloromethane (40 ml) at room temperature. After stirring for 30 min the solvent and methanesulfenyl chloride formed in the reaction were distilled off at reduced pressure. The residual material was used for alkylation without further purification. 1H NMR (CDCl3): δ5.13 (CH2), 5.47 (CH2Cl), 7.2-8.3 (Naph).

後処理

  1. customformed in the reaction
  2. distillationwere distilled off at reduced pressure
  3. customThe residual material was used for alkylation without further purification

出典と根拠

ORDレコード
ord-a69b9863163d4784871dc425371f3af4
出典データセット
uspto-grants-1985_09
特許番号
US04539324

反応ノート

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