Diisopropyl Ether → R 57720

反応式

[N+]([O-])(O)=O.[Cl:5]/[C:6](/[C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=1[Cl:20])=[CH:7]\[N:8]1[CH:12]=[CH:11][N:10]=[CH:9]1.O(C(C)C)C(C)C.[OH-].[NH4+]>O>[ClH:5].[Cl:5]/[C:6](/[C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=1[Cl:20])=[CH:7]\[N:8]1[CH:12]=[CH:11][N:10]=[CH:9]1

参加物

実験手順

To a stirred mixture of 12.76 parts of (Z)-1-[2-chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-imidazole mononitrate, 120 parts of water and 70 parts of 2,2'-oxybispropane were added 3.5 parts of ammonium hydroxide. The whole was stirred till homogeneous. The layers were separated. The aqueous phase was extracted with 35 parts of 2,2'-oxybispropane. The combined organic layers were washed with water, dried, filtered and evaporated in vacuo. The residue was converted into the hydrochloride salt in 64 parts of 2-propanone. The salt was filtered off, washed with 2-propanone and dried in vacuo, yielding 8.54 parts of (Z)-1-[2-chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-imidazole monohydrochloride; mp. 178.8° C. (compound 3).