Thionyl Chloride → 5-Methyl-4-imidazolecarbonyl chloride hydrochloride
反応式
[ClH:1].[CH3:2][C:3]1[NH:7][CH:6]=[N:5][C:4]=1[C:8]([OH:10])=O.S(Cl)([Cl:13])=O>CN(C)C=O.C1(C)C=CC=CC=1>[ClH:13].[CH3:2][C:3]1[NH:7][CH:6]=[N:5][C:4]=1[C:8]([Cl:1])=[O:10]参加物
5
反応条件
- 温度
- 80 °C
実験手順
To a suspension of 880 g (5.4 moles) of 5-methyl-4-imidazolecarboxylic acid hydrochloride in 100 ml of dimethylformamide and 2 liters of toluene at 60° C., there was added slowly over 2 hours 790 ml (10.8 moles) of thionyl chloride. At the end of the addition, the mixture was held with good stirring for 1 hour at 80° C. It was allowed to cool, filtered, the solid was washed with 1 liter of toluene. 685 g of 5-methyl-4-imidazolecarbonyl chloride hydrochloride were obtained.
後処理
- additionAt the end of the addition
- temperatureto cool
- filtrationfiltered
- washthe solid was washed with 1 liter of toluene
出典と根拠
- ORDレコード
- ord-1508279536a140268bb6e1de6bc96243
- 出典データセット
- uspto-grants-1985_09
- 特許番号
- US04539331
反応ノート
読み込み中…