Hydrochloric Acid → 1-(5-Carboxypentyl)-2-(1-imidazolyl)-3-methylindole hydrochloride

HRID 1719377

反応式

HRID 1719377 の反応式
C[O:2][C:3]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][N:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12]([CH3:19])=[C:11]1[N:20]1[CH:24]=[CH:23][N:22]=[CH:21]1)=[O:4].[OH-].[Na+].[ClH:27]>C(O)C.C(OCC)C>[ClH:27].[C:3]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][N:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12]([CH3:19])=[C:11]1[N:20]1[CH:24]=[CH:23][N:22]=[CH:21]1)([OH:4])=[O:2]

参加物

6

反応物 3

HCID 313Hydrochloric Acid2 回HCID 14798Sodium HydroxideHCID 132808401-(5-Methoxycarbonylpentyl)-2-(1-imidazolyl)-3-methylindole

生成物 1

HCID 202681941-(5-Carboxypentyl)-2-(1-imidazolyl)-3-methylindole hydrochloride

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒2 回HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 1-(5-methoxycarbonylpentyl)-2-(1-imidazolyl)-3-methylindole (1.80 g) and 30 ml of 3N NaOH is stirred at room temperature for 1.3 hours. The resulting clear, yellow solution is neutralized to pH 6 with 2N HCl. The resulting suspension is extracted with ethyl acetate (2×50 ml). The organic extract is washed with a saturated NaCl solution (1×25 ml), dried (MgSO4), filtered, and concentrated in vacuo to give a cream-colored solid. The solid is dissolved in ethanol and the solution treated with 0.6 ml of 6.5N HCl in ethanol. The solution is diluted with diethyl ether and after standing for several hours the precipitate which forms is collected by filtration to give 1-(5-carboxypentyl)-2-(1-imidazolyl)-3-methylindole hydrochloride, m.p. 177.5°-180.5° decomposition.

後処理

  1. extractionThe resulting suspension is extracted with ethyl acetate (2×50 ml)
  2. extractionThe organic extract
  3. washis washed with a saturated NaCl solution (1×25 ml)
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo
  7. customto give a cream-colored solid
  8. waitafter standing for several hours
  9. filtrationthe precipitate which forms is collected by filtration

出典と根拠

ORDレコード
ord-90188c2ea98f4ed7b689613b8d334c9a
出典データセット
uspto-grants-1985_09
特許番号
US04539410

関連ノート

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