Thionyl Chloride → 1-(6-Chlorohexyl)-3-methyl-2-(1-imidazolyl)indole

HRID 1719400ノート

反応式

HRID 1719400 の反応式
S(Cl)([Cl:3])=O.O[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:14]([CH3:21])=[C:13]1[N:22]1[CH:26]=[CH:25][N:24]=[CH:23]1.C(=O)(O)[O-].[Na+]>>[Cl:3][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:14]([CH3:21])=[C:13]1[N:22]1[CH:26]=[CH:25][N:24]=[CH:23]1

参加物

4

反応物 3

HCID 24386Thionyl ChlorideHCID 516892Sodium BicarbonateHCID 202681751-(6-Hydroxyhexyl)-3-methyl-2-(1-imidazolyl)indole

生成物 1

HCID 202681921-(6-Chlorohexyl)-3-methyl-2-(1-imidazolyl)indole

実験手順

Thionyl chloride (0.36 ml) is combined with 1-(6-hydroxyhexyl)-3-methyl-2-(1-imidazolyl)indole (1.3 g) at 0°. The mixture is then stirred at room temperature for 1 hour. Saturated aqueous sodium bicarbonate is added and the mixture is extracted with dichloromethane. The extract is washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. Concentration to dryness and purification by chromatography gives 1-(6-chlorohexyl)-3-methyl-2-(1-imidazolyl)indole.

後処理

  1. extractionthe mixture is extracted with dichloromethane
  2. washThe extract is washed with saturated sodium chloride solution
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationConcentration
  5. customto dryness and purification by chromatography

出典と根拠

ORDレコード
ord-322df61102c04e409372e62941e69904
出典データセット
uspto-grants-1985_09
特許番号
US04539410

反応ノート

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