Formaldehyde → 1,2-Diphenyl-4-[2-(phenylsulfinyl)ethyl]-4-hydroxymethyl-pyrazolidine-3,5-dione

HRID 1719691ノート

反応式

HRID 1719691 の反応式
[CH2:1]=[O:2].[C:3]1([N:9]2[C:13](=[O:14])[CH:12]([CH2:15][CH2:16][S:17]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[O:18])[C:11](=[O:25])[N:10]2[C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>CO>[C:26]1([N:10]2[C:11](=[O:25])[C:12]([CH2:15][CH2:16][S:17]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)=[O:18])([CH2:1][OH:2])[C:13](=[O:14])[N:9]2[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

参加物

4

反応物 2

HCID 712FormaldehydeHCID 5342Sulfinpyrazone

生成物 1

HCID 202664801,2-Diphenyl-4-[2-(phenylsulfinyl)ethyl]-4-hydroxymethyl-pyrazolidine-3,5-dione

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
50 °C

実験手順

40% Formaline (25 ml) is added to a solution of 20 grams of 1,2-diphenyl-4-[2-(phenylsulfinyl)-ethyl]-pyrazolidine-3,5-dione in 120 ml of methanol. The solution, under magnetic stirring, is heated up to 50° C. for one hour and kept, always under a magnetic stirring, at room temperature for 12 hours. At the end the solvent is evaporated under reduced pressure, the residue is washed with water and extracted with dichloromethane.

後処理

  1. customAt the end the solvent is evaporated under reduced pressure
  2. washthe residue is washed with water
  3. extractionextracted with dichloromethane

出典と根拠

ORDレコード
ord-deb660bfe1394394b7490124f25e7769
出典データセット
uspto-grants-1985_09
特許番号
US04542141

反応ノート

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