Sodium Hydroxide → HCID 20266533、化合物

HRID 1719697ノート

反応式

HRID 1719697 の反応式
Cl.Cl.[N:3]1([CH2:8][CH2:9][NH2:10])[CH:7]=[N:6][CH:5]=[N:4]1.[OH-].[Na+].[Cl:13][C:14]1[C:15]2[CH:25]=[CH:24][CH:23]=[CH:22][C:16]=2[S:17][C:18]=1[C:19](Cl)=[O:20]>C(Cl)Cl>[Cl:13][C:14]1[C:15]2[CH:25]=[CH:24][CH:23]=[CH:22][C:16]=2[S:17][C:18]=1[C:19]([NH:10][CH2:9][CH2:8][N:3]1[CH:7]=[N:6][CH:5]=[N:4]1)=[O:20]

参加物

5

反応物 3

HCID 14798Sodium Hydroxide2 回HCID 5198983-Chlorobenzo(b)thiophene-2-carbonyl chlorideHCID 202483172-(1H-1,2,4-triazol-1-yl)ethan-1-amine dihydrochloride

生成物 1

HCID 20266533HCID 20266533、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A mixture of about 1.85 g of 1H-1,2,4-triazole-1ethanamine dihydrochloride, about 50 ml of methylene chloride, about 30 ml of 1N sodium hydroxide and about 2.3 g of 3-chlorobenzo-[b]thiophene carbonyl chloride was stirred for about 16 hours. A 50 ml portion of methylene chloride and about 5 ml of 1N sodium hydroxide were added and the layers were separated. The organic layer was washed twice with water dried and concentrated, giving the desired compound, mp 151°-152° C.

後処理

  1. customthe layers were separated
  2. washThe organic layer was washed twice with water
  3. customdried
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-a92851b8014b407a8efc7ee0a115814c
出典データセット
uspto-grants-1985_09
特許番号
US04542145

反応ノート

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