Methyl iodide → 5-Chloro-3-methyl-3-phenyl-1,3-dihydro-2H-indol-2-one

HRID 1719722ノート

反応式

HRID 1719722 の反応式
[C:1]1([CH:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([Cl:16])[CH:14]=3)[NH:9][C:8]2=[O:17])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:18](=O)([O-])[O-].[K+].[K+].CI>CC(C)=O.O>[CH3:18][C:7]1([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([Cl:16])[CH:14]=2)[NH:9][C:8]1=[O:17]

参加物

6

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 190764863-Phenyl-5-chlorooxindole

生成物 1

HCID 202330995-Chloro-3-methyl-3-phenyl-1,3-dihydro-2H-indol-2-one

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 962Water溶媒

反応条件

温度
50 °C

実験手順

10 g of 3-phenyl-5-chlorooxindole were dissolved in 100 ml of acetone and 20 ml of water, 2.9 g of potassium carbonate and 2.9 ml of methyl iodide were added and the mixture was warmed at 50° C. for 3 hours and concentrated; water was added to the residue, which was extracted with ethyl acetate, and the extract was dried over magnesium sulfate, and the solvent was removed. The residue was recrystallized from ethanol. Melting point 180°-181° C.

後処理

  1. concentrationconcentrated
  2. additionwater was added to the residue, which
  3. extractionwas extracted with ethyl acetate
  4. dry with materialthe extract was dried over magnesium sulfate
  5. customthe solvent was removed
  6. customThe residue was recrystallized from ethanol

出典と根拠

ORDレコード
ord-b624a3498210448dbab3855c17e63bb3
出典データセット
uspto-grants-1985_09
特許番号
US04542148

反応ノート

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