Methane → 5-Methoxynaphthalen-1-amine

HRID 1719863ノート

反応式

HRID 1719863 の反応式
O.NN.[CH3:4][O:5][C:6]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:7]=1[CH:8]=[CH:9][CH:10]=[C:11]2[N+:16]([O-])=O.C.NN>C(O)C>[NH2:16][C:11]1[C:12]2[C:7](=[C:6]([O:5][CH3:4])[CH:15]=[CH:14][CH:13]=2)[CH:8]=[CH:9][CH:10]=1

参加物

6

反応物 4

HCID 297Methane2 回HCID 9321HydrazineHCID 24654Hydrazine hydrate (1:1)HCID 127385811-Methoxy-5-nitronaphthalene

生成物 1

HCID 2355485-Methoxynaphthalen-1-amine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
50 °C

実験手順

Hydrazine hydrate (150 ml) is added slowly to a stirred mixture of 5-methoxy-1-nitro-naphthalene (320 g), and palladized charcoal (0.1 g) in 95% ethanol (2 liters) previously warmed to 50° C. When the hydrazine addition is complete, additional palladized charcoal (0.1 g) is added and the mixture heated to reflux for about one hour. The reaction mixture is filtered through Celite and the filtrate evaporated in vacuo resulting in a white solid which is recrystallized from H2O and ethanol.

後処理

  1. temperaturethe mixture heated
  2. temperatureto reflux for about one hour
  3. filtrationThe reaction mixture is filtered through Celite
  4. customthe filtrate evaporated in vacuo
  5. customresulting in a white solid which
  6. customis recrystallized from H2O and ethanol

出典と根拠

ORDレコード
ord-e95988124cf644d59d2bc3b9b51a4a22
出典データセット
uspto-grants-1985_09
特許番号
US04543352

反応ノート

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