2-Phenyl-1-(1H-pyrrol-2-yl)ethan-1-one → HCID 13220943、化合物
反応式
[C:1]1([CH2:7][C:8]([C:10]2[NH:11][CH:12]=[CH:13][CH:14]=2)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH2:8]([C:10]1[NH:11][CH:12]=[CH:13][CH:14]=1)[CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1参加物
4
実験手順
Compound (III) is dissolved in an ethereal solvent, preferably anhydrous tetrahydrofuran, and a complex metal hydride, preferably lithium aluminum hydride, is added. The mixture is reacted at reflux temperature for 35-53 hours, preferably 48 hours. Excess of hydride is destroyed with organic solvent and the reaction mixture is purified by methods known to the art to afford 2-[phenethyl]pyrrole (IV).
後処理
- customThe mixture is reacted
- temperatureat reflux temperature for 35-53 hours
- custompreferably 48 hours
- customExcess of hydride is destroyed with organic solvent
- customthe reaction mixture is purified by methods
出典と根拠
- ORDレコード
- ord-f0567ab360e6480fb6e0d0905e5cf1ce
- 出典データセット
- uspto-grants-1985_09
- 特許番号
- US04543361
反応ノート
読み込み中…