Dichloromethane → 3-Isopropyl-4-(2-acetoxyethyl)-azetidinone
反応式
[CH:1]([C@H:4]1[C@H:7]([CH2:8][CH2:9][OH:10])[NH:6][C:5]1=[O:11])([CH3:3])[CH3:2].C(Cl)Cl.[C:15](Cl)(=[O:17])[CH3:16]>N1C=CC=CC=1>[CH:1]([CH:4]1[CH:7]([CH2:8][CH2:9][O:10][C:15](=[O:17])[CH3:16])[NH:6][C:5]1=[O:11])([CH3:3])[CH3:2]参加物
5
実験手順
Trans-3-isopropyl-4-(2-hydroxyethyl)-2-azetidinone from Step B, is dissolved in 10 ml. CH2Cl2 and cooled to 0° C. Pyridine 0.75 ml is added and then 0.392 ml of acetyl chloride is added dropwise. The mixture is stirred at 0° for 15 min and then at 25° C. for another 15 minutes. The reaction mixture is evaporated to dryness. The residue is chromatographed on silica gel using 50% EtOAc/C6H6 as eluant to give 0.652 g 3-isopropyl-4-(2-acetoxyethyl)-azetidinone.
後処理
- waitat 25° C. for another 15 minutes
- customThe reaction mixture is evaporated to dryness
- customThe residue is chromatographed on silica gel using 50% EtOAc/C6H6 as eluant
出典と根拠
- ORDレコード
- ord-fe8082f01ee044b29c4da929b49dc7bb
- 出典データセット
- uspto-grants-1985_09
- 特許番号
- US04543257
反応ノート
読み込み中…