Glutaric anhydride → 5-Oxo-5-(4-pentylphenyl)pentanoic acid

HRID 1720138

反応式

HRID 1720138 の反応式
[C:1]1(=[O:8])[O:7][C:5](=[O:6])[CH2:4][CH2:3][CH2:2]1.[CH2:9]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:10][CH2:11][CH2:12][CH3:13].[Cl-].[Al+3].[Cl-].[Cl-]>Cl>[CH2:9]([C:14]1[CH:15]=[CH:16][C:17]([C:5]([CH2:4][CH2:3][CH2:2][C:1]([OH:7])=[O:8])=[O:6])=[CH:18][CH:19]=1)[CH2:10][CH2:11][CH2:12][CH3:13]

参加物

5

反応物 3

HCID 7940Glutaric anhydrideHCID 10864PentylbenzeneHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 152955605-Oxo-5-(4-pentylphenyl)pentanoic acid

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

Glutaric anhydride (10 g; 0.1mole) is reacted with pentylbenzene (100 ml) and aluminum chloride (29 g; 0.22 mole) at room temperature for 4 hours. The reaction mixture is poured into a mixture of ice-water (500 ml) and concentrated hydrochloric acid (50 ml) with vigorous stirring. The crude product is collected by filtration and recrystallized from aqueous ethanol to give 4-(4-n-pentylbenzoyl)butanoic acid (16.2 g) as colorless crystals, m.p. 104°-106° C.

後処理

  1. filtrationThe crude product is collected by filtration
  2. customrecrystallized from aqueous ethanol

出典と根拠

ORDレコード
ord-1e697da2d277461f875d566082667c27
出典データセット
uspto-grants-1996_04
特許番号
US05504244

関連ノート

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