Water → 1-(2-Anilinoethyl)-4-methoxymethoxypiperidine

HRID 1720296ノート

反応式

HRID 1720296 の反応式
[NH:1]([C:8]([CH2:10][N:11]1[CH2:16][CH2:15][CH:14]([O:17][CH2:18][O:19][CH3:20])[CH2:13][CH2:12]1)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[K+].O>O1CCCC1.C(OCC)(=O)C>[NH:1]([CH2:8][CH2:10][N:11]1[CH2:16][CH2:15][CH:14]([O:17][CH2:18][O:19][CH3:20])[CH2:13][CH2:12]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

7

反応物 4

HCID 962WaterHCID 14797Potassium HydroxideHCID 21226445Aluminium lithium hydrideHCID 229236881-(Anilinocarbonylmethyl)-4-methoxymethoxypiperidine

生成物 1

HCID 229237061-(2-Anilinoethyl)-4-methoxymethoxypiperidine収率 98.6%

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒2 回HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 3.64 g of 1-(anilinocarbonylmethyl)-4-methoxymethoxypiperidine in 10 ml of tetrahydrofuran was added to a suspension of 630 mg of lithium aluminum hydride in 50 ml of tetrahydrofuran. The mixture was refluxed for 3 hours. To the reaction mixture were added 1.5 ml of an aqueous solution containing 10% of potassium hydroxide and 1.5 ml of water. The mixture was diluted with ethyl acetate, and the dilution was filtered. The solvent in the filtrate was removed by distillation to obtain 3.41 g of 1-(2-anilinoethyl)-4-methoxymethoxypiperidine.

後処理

  1. temperatureThe mixture was refluxed for 3 hours
  2. filtrationthe dilution was filtered
  3. customThe solvent in the filtrate was removed by distillation

出典と根拠

ORDレコード
ord-c3ad9d8cfb27477b9f7d01af74960ffe
出典データセット
uspto-grants-1996_04
特許番号
US05506239

反応ノート

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