(3,4-Dichlorophenoxy)acetic acid → (+/-)-trans-N-methyl-N-[2-(1-hexahydroazepinyl)cyclohexyl](3,4-dichlorophenoxy)acetamide monohydrochloride

HRID 1720376

反応式

HRID 1720376 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]=1[Cl:13])[O:5][CH2:6][C:7]([OH:9])=O.[CH3:14][NH:15][C@@H:16]1[CH2:21][CH2:20][CH2:19][CH2:18][C@H:17]1[N:22]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>>[ClH:1].[CH3:14][N:15]([C@@H:16]1[CH2:21][CH2:20][CH2:19][CH2:18][C@H:17]1[N:22]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1)[C:7](=[O:9])[CH2:6][O:5][C:4]1[CH:10]=[CH:11][C:12]([Cl:13])=[C:2]([Cl:1])[CH:3]=1

参加物

3

反応物 2

HCID 11495(3,4-Dichlorophenoxy)acetic acidHCID 53677879HCID 53677879、化合物

生成物 1

HCID 67685166(+/-)-trans-N-methyl-N-[2-(1-hexahydroazepinyl)cyclohexyl](3,4-dichlorophenoxy)acetamide monohydrochloride

実験手順

The title compound was prepared according to the method described in Example 2, using 3,4-dichlorophenoxyacetic acid (2.15 g, 10 mmol) and (±)-trans-N-methyl-N-[2-(1-hexahydroazepinyl)cyclohexyl]amine prepared in Example 10 (2 g, 10 mmol). The crude product, which precipitated without the addition of any diethyl ether, was recrystallised from hot methanol (150 mL). Yield 3.58 g (80%).

後処理

  1. customThe crude product, which precipitated without the addition of any diethyl ether
  2. customwas recrystallised from hot methanol (150 mL)

出典と根拠

ORDレコード
ord-9f194e8c2ff341d6a49751e81e3dc9ac
出典データセット
uspto-grants-1996_04
特許番号
US05506257

関連ノート

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