Methanol → Capryloyl proline

HRID 1720519ノート

反応式

HRID 1720519 の反応式
C([O:8][C:9](=[O:24])[C@@H:10]1[CH2:14][CH2:13][CH2:12][N:11]1[C:15](=[O:23])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])C1C=CC=CC=1.CO>O.[Pd]>[C:15]([N:11]1[CH2:12][CH2:13][CH2:14][C@H:10]1[C:9]([OH:24])=[O:8])(=[O:23])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

参加物

5

反応物 2

HCID 887MethanolHCID 53996545N-octanoyl-L-proline benzyl ester

生成物 1

HCID 18632639Capryloyl proline収率 99.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 962Water溶媒

実験手順

To a solution of N-octanoyl-L-proline benzyl ester (7.04 g) in 1% water-containing methanol (70 ml) was added 10% Pd-C (0.71 g), and the mixutre was stirred under hydrogen atmosphere at room temperature for 1.5 hours. After the catalyst was filtered off, the filtrate was concentrated to give 5.08 g of the title compound.

後処理

  1. filtrationAfter the catalyst was filtered off
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-1f11259e02a84f41a64a9d273c3fed9f
出典データセット
uspto-grants-1996_04
特許番号
US05506256

反応ノート

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