Hydrochloric Acid → Methyl alpha-(hydroxy methylene)-2-isopropyl-4-[(E)-styryl]-5-thiazolacetate

HRID 1721026ノート

反応式

HRID 1721026 の反応式
CN([CH:4]=[C:5]([C:10]1[S:14][C:13]([CH:15]([CH3:17])[CH3:16])=[N:12][C:11]=1/[CH:18]=[CH:19]/[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:6]([O:8][CH3:9])=[O:7])C.Cl.[O:27]1CCCC1>>[OH:27][CH:4]=[C:5]([C:10]1[S:14][C:13]([CH:15]([CH3:17])[CH3:16])=[N:12][C:11]=1/[CH:18]=[CH:19]/[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:6]([O:8][CH3:9])=[O:7]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 67766585HCID 67766585、化合物

生成物 1

HCID 67766718Methyl alpha-(hydroxy methylene)-2-isopropyl-4-[(E)-styryl]-5-thiazolacetate

実験手順

2 g of the enamine of Step F, 20 ml of tetrahydrofuran and 5 ml of a 2N hydrochloric acid solution were mixed together under nitrogen and left for 5 hours at 20° to 21° C. The tetrahydrofuran was evaporated off and the product was used as is for the following step.

後処理

  1. customThe tetrahydrofuran was evaporated off

出典と根拠

ORDレコード
ord-34c0981ed9824859acc40564af7ecf9a
出典データセット
uspto-grants-1996_04
特許番号
US05508414

反応ノート

読み込み中…