Methane → 5,6-Dihydroxyindole
反応式
[N+]([C:4]1[CH:9]=[C:8]([O:10]CC2C=CC=CC=2)[C:7]([O:18]CC2C=CC=CC=2)=[CH:6][C:5]=1[CH2:26][C:27]#[N:28])([O-])=O.C.C(O)C>[Pd].O>[OH:18][C:7]1[CH:6]=[C:5]2[C:4](=[CH:9][C:8]=1[OH:10])[NH:28][CH:27]=[CH:26]2参加物
6
反応条件
- 温度
- 80 °C
実験手順
The reaction mixture is prepared in an autoclave by adding 0.04 mole (15 g) of 2-nitro-4,5-dibenzyloxyphenylacetonitrile, 1.5 g of palladium at a concentration of 10% on charcoal and 1.5 g of charcoal to 120 ml of ethanol containing 3 ml of water. These are heated to 80° C. for 2 hours, with stirring, under a hydrogen pressure of 4.105Pa. After cooling, the reaction mixture, which is treated in the same manner as previously, produces 5,6-dihydroxyindole in an equivalent yield.
後処理
- customThe reaction mixture is prepared in an autoclave
- temperatureAfter cooling
- additionthe reaction mixture, which is treated in the same manner as previously,
出典と根拠
- ORDレコード
- ord-f21020e9fa9b4b739ae9fb61b7523e59
- 出典データセット
- uspto-grants-1996_04
- 特許番号
- US05508464
反応ノート
読み込み中…