Sodium hydride → HCID 22414273、化合物
反応式
Cl[C:2]1[CH:11]=[C:10]([CH3:12])[C:9]2[C:4](=[CH:5][C:6]([Cl:13])=[CH:7][CH:8]=2)[N:3]=1.[CH3:14][O-:15].[Na+].[H-].[Na+]>CO>[Cl:13][C:6]1[CH:5]=[C:4]2[C:9]([C:10]([CH3:12])=[CH:11][C:2]([O:15][CH3:14])=[N:3]2)=[CH:8][CH:7]=1参加物
5
実験手順
2-Chloroquinoline 14 (7.0 g; 32.8 mmol) was added to a solution of sodium methoxide in methanol generated from 1.08 g (36.1 mmol) of 80% sodium hydride in 80 ml of methanol. The resulting mixture was refluxed overnight. It was filtered while still hot to remove undissolved matter. The product crystallized from the methanol upon cooling to deliver 6.1 g (70%) of 15 as a white solid. 1H NMR (CDCl3);: δ2.62 (s, 3H); 4.10 (s, 3H); 6.78 (s, 1H); 7.38 (d, 1H); 7.81 (d, 1H); 7.93 (d, 1H).
後処理
- temperatureThe resulting mixture was refluxed overnight
- filtrationIt was filtered while still hot
- customto remove undissolved matter
- customThe product crystallized from the methanol
- temperatureupon cooling
出典と根拠
- ORDレコード
- ord-c1ad68f68b5e4751aaba5d3a8df1a1de
- 出典データセット
- uspto-grants-1996_04
- 特許番号
- US05510338
反応ノート
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