Dicyclohexylcarbodiimide → N,N'-Dicyclohexylurea

Dehydroryanodine (100 mg, 0.2 mmol), N-(p-iodobenzoyl)-β-alanine (50 mg, 0.22 mmol) and DMAP (2 mg, 0.02 mmol), all dried over P2O5, were dissolved in a solvent mixture of CH2Cl2 (10 ml) and tetrahydrofuran (0.1 ml) dried over Molecular Sieve. To the stirred solution, dicyclohexylcarbodiimide (DCC, 52 mg., 0.25 mmol) was added at once and the stirred reaction maintained at room temperature for 6 hours. Water (0.1 ml) was added to inactivate excess DCC and stirring was continued for 30 minutes. The crystals of dicyclohexylurea thus formed were filtered off and washed twice with CH2Cl2.

1. customdried over Molecular Sieve
2. customthe stirred reaction

ORDレコード

ord-3ae35235d3aa422faa1cab132c0edf38

出典データセット

uspto-grants-1996_04

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05510500