Ethanol → HCID 10926216、化合物
反応式
[CH2:1]1CCC(N=C=NC2CCCCC2)C[CH2:2]1.[C:16]([O:20][C:21]([NH:23][CH2:24][P:25]([CH2:28][NH:29][C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])(=[O:27])[OH:26])=[O:22])([CH3:19])([CH3:18])[CH3:17].C(O)C>C1COCC1>[C:16]([O:20][C:21]([NH:23][CH2:24][P:25]([CH2:28][NH:29][C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])(=[O:26])[O:27][CH2:1][CH3:2])=[O:22])([CH3:19])([CH3:18])[CH3:17]参加物
5
実験手順
DCC (190 mg; 0.92 mmol) in THF (4 ml) is added dropwise over the course of 4 minutes to a solution of the phosphinic acid 1 (270 mg; 0.83 mmol) in dry THF (4 ml) and absolute ethanol (0.30 ml; 5.15 mmol) which is boiling under reflux. After 1.5 hours (check via DC) the reaction solution is cooled to room temperature and filtered. The filtration residue is washed with ether.